It is best used in close-quarters combat. However, the stats do not correctly reflect it's performance as actually, the gun is far less accurate at range than the P228 and has shorter range for mark and execute. The weapon is overall very balanced without any upgrades with all of them, the USP.45 is statistically a more powerful, slightly lower capacity P228, with all other stats being nearly identical. Unlike it's larger sibling, the MK.23, the USP.45 is not equipped with a suppressor. The USP.45 is the last pistol unlocked in story mode, available after you complete the Lincoln Memorial mission, where it is the pistol used to kill Lucius Galliard. ' Powerful and accurate at medium ranges, the USP.45 is one of the most trustworthy sidearms.'